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Collaborators - coming soon
Key Publications

  • Mason R., Groves I.J., Wills M.R., Sinclair J.H. & Reeves M.B. (2020) Human cytomegalovirus major immediate-early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells. J. Gen. Virol. 101(6):635-44

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  • Baraniak, I., Gomes A., Sodi I., Langstone T., Rothwell E., Atkinson C., Piras-Douce F., Pichon S., Griffiths P. & Reeves M.B. (2019) Seronegative patients vaccinated with the cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation Lancet EBioMedicine 50:45-54

 

  • Dupont L., Du L., Poulter M., Choi S., McIntosh M. & Reeves M.B. (2019) Src family kinase activity drives cytomegalovirus reactivation through recruitment of MOZ histone acetyltransferase activity J. Biol. Chem. 294(35):12901-1291

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  • Poole E.L., Lau J.C.H., Murray, M.J., Kew V.G., Stamminger T., Sinclair J.H. & Reeves M.B. (2018) A virally dependent de-sumoylase activity is required for HCMV reactivation from latency Cell Reports 24(3):594-606

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  • Baraniak I, Kropff B, Ambrose L, McIntosh M, McLean, G, Pichon S,Atkinson C, Milne R.,Mach, M., Griffiths P. & Reeves M.B. (2018) Protection from cytomegalovirus viraemia following glycoprotein B vaccination is not dependent on neutralising antibodies PNAS 115(24):6273-627

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  • Baraniak I.... Reeves M.B. (2018) Epitope mapping of the humoral immune response against HCMV glycoprotein B following vaccination with gB/MF59 prior to transplant. Journal of Infectious Diseases jiy102, https://doi.org/10.1093/infdis/jiy102

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  • Kew V.G., Yuan, J., Meier, J. & Reeves M.B. (2014) Mitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus gene expression from latency. PLoS Pathogens10(6):e1004195

 

  • Huang M.M., Kew V.G., Jestice K., Wills M.R. & Reeves M.B. (2012) Efficient human cytomegalovirus reactivation is maturation dependent in the Langerhans dendritic cell lineage and can be studied using a CD14+ experimental latency model. J. Virol. 86(16):8507-15

 

  • Reeves M.B., Breidenstein A. & Compton T. (2012) Human cytomegalovirus activation of ERK and myeloid cell leukaemia-1 protein correlates with survival of latently infected cells. PNAS 109(2): 588-93

 

  • Reeves M.B. & Compton T. (2011) Inhibition of inflammatory interleukin-6 activity via extracellular signal-related-mitogen activated protein kinase antagonizes human cytomegalovirus reactivation from dendritic cells. J. Virol. 85(23): 12750-8

 

  • Reeves M.B., Davies A.A., McSharry B.P., Wilkinson G.W. and Sinclair J.H. (2007) A virally encoded RNA molecule protects infected cells from mitochondrial-induced cell death. Science 316(5829): 1345-8 see also Perspectives section in Science 317(5836):  329-30

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  • Reeves M.B., Lehner P.J., Sissons J.G.P. and Sinclair J.H. (2005) An in vitro model for the regulation of HCMV latency and reactivation in dendritic cells by chromatin remodeling. J. Gen. Virol 86(11): 2949-54

 

  • Reeves M.B., MacAry P.A., Lehner P.J., Sissons J.G.P. and Sinclair J.H. (2005) Latency, chromatin remodeling and reactivation of HCMV in the dendritic cells of healthy carriers. PNAS 102(11): 4140-5

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