Matt Chair-Elect for Virology Division, Microbiology Society
Matt has been invited to serve as Chair of the Microbiology Society Virology Division from 2023. He takes up the post as Chair-Elect (2021) before taking over the reigns from current incumbent Jo Parish (Birmingham).
Welcome to Ines, Callum and Rahinat
We welcome Ines (PhD student) and MSC students Callum and Rahinat to the lab. They will be working on various aspects of HCMV cell biology including haematopiesis, miRNA control of HCMV latent infection and tissue immune responses. Looking forward to the next few months
Microbiology Society Meeting
It's that time again - it's the annual Microbiology Society meeting (SGM in old money). Matt R is co-responsible for organising and wil chair the DNA virus workshop. This in no way impacted on the decision to allow Matt and Calum to talk about their work.
HCMV/HSV latency giant lab meeting
The Reeves lab attended and presented at the Giant lab meeting initiated by Rob Kalejta and Donna Neumann (Wisconsin) and fantastically organised by trainees from a number of laboratories around the world including Matt from UCL. A great initiative in these times and it may well become a fixture in the calendar as it is great to talk about new ideas in the lab meeting setting rather than the more polished stories presented at conferences.
Congratulations to Matt on the acceptance and publication of his manuscript detailing the use of an ELISA based assay as a surrogate measure of the neutralising antibody response to SARS-CoV-2 Spike protein. Matt has driven this project forward along with UCL colleagues Claire, Meg and Tabi and collabroators at HSL (Mike and Wendy) and Sussex (Ed Wright). Well done to everyone involved and also for the support of this work through the philanthropic support of the UCL Coronavirus fund.
Also congratulations to our collaborators in Cambridge (Mark Wills and John Sinclair) who have just had their study concerning viral recruitment of T cells that promotes reactivation. The work has been accepted in Frontiers of Immunology.
New SARS pre-print
Also take a look at new work we were involved with and also supported by the UCL Coronavirus fund.
This was a Team UCL effort led by Joe Grove along with Samuel Dicken and Matt M. It suggests that SARS-CoV-2 Spike hasnt achieved its full potential yet but perhaps more reassuringly does suggest that antibodies against original SARS-CoV-2 are active against the UK variant. The vaccine should still work!
We welcome Oliver Thomas to the lab who is joining us for a PhD rotation project to identify candidate molecules important for the establishment of latency utilsiing a miRNAome analysis we have performed. Oliver is on the MRC Birkbeck PhD programme.
Congrats to our collaborator, Gary McLean at London Met who has had his study of IgA responses to gB of HCMV accepted in Immunology. A really nice piece of work that involved Meg, Josh and Ariane from our lab and demonstrated IgA antibodies against HCMV gB are potent neutralising antibodies and, intriguingly, are present at very high levels in breast milk. Implications for passive immunisation from mother to child. Well done Saima (lead author) and all.