Recent Publications
  • M.J. Murray, N.I. Bonilla-Medrano, Q.L. Lee, S.J. Oxenford, R. Angell, D.P. Depledge, M.B. Reeves (2020) Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilisation of a heparan sulfate proteoglycan independent route of entry.  Journal of Virology, JVI.02012-19; DOI: 10.1128/JVI.02012-19

  • Baraniak, I., Gomes, A., Sodi, I., Langstone, T., Rothwell, E., Atkinson, C., Piras-Douce, F., Pichon, S., Griffiths, P. & Reeves M.B. (2019) Seronegative patients vaccinated with the cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation Lancet EBioMedicine 50:45-54

  • Dupont L, Du L, Poulter M, Choi S, McIntosh M, Reeves MB. (2019). Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter. J Biol Chem 294:jbc.RA119.009667.
     

  •  Baraniak I., Kern F., Holenya P., Griffiths P.D. & Reeves M.B. (2019) Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients. J. Inf. Dis. pii:jiz089

  • Alsaady I, Tedford E, Alsaad M, Bristow G, Kohli S, Murray M, Reeves M, Vijayabaskar MS, Clapcote SJ, Wastling J, McConkey GA. (2019). Downregulation of the central noradrenergic system by Toxoplasma gondii infection. Infect Immun 87:e0078918. https://doi.org/10.1128/IAI.00789-18.
     

  • Poole E.L., Lau J.C.H., Murray, M.J., Kew V.G., Stamminger T., Sinclair J.H. & Reeves M.B. (2018) A virally dependent de-sumoylase activity is required for HCMV reactivation from latency Cell Reports 24(3):594-606

  • Baraniak I, Kropff B, Ambrose L, McIntosh M, McLean, G, Pichon S,Atkinson C, Milne R.,Mach, M., Griffiths P. & Reeves M.B. (2018) Protection from cytomegalovirus viraemia following glycoprotein B vaccination is not dependent on neutralising antibodies PNAS 115(24):6273-6278

  • Also see editorial: Schleiss M.R. Recombinant cytomegalovirus glycoprotein B vaccine: Rethinking the immunological basis of protection

 

  • Baraniak I.... Reeves M.B. (2018) Epitope mapping of the humoral immune response against HCMV glycoprotein B following vaccination with gB/MF59 prior to transplant. Journal of Infectious Diseases jiy102, https://doi.org/10.1093/infdis/jiy102

 

  • Pocock J., Storisteanu, D., Reeves M.B., Juss J., Wills, M., Cowburn A. & Chilvers E. (2017) Human cytomegalovirus delays neutrophil apoptosis and stimulates the release of a pro-survival secretome. Frontiers in Immunology https://doi.org/10.3389/fimmu.2017.01185

 

  • Kew V.G., Wills M.R. & Reeves M.B. (2017) HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors. J. Mol. Biochem. 6(1):13-25

 

  • Kew V.G., Wills M.R. & Reeves M.B. (2017) LPS promotes a monocyte phenotype permissive for human cytomegalovirus immediate early gene expression upon infection but not reactivation from latency. Sci. Reports 7: 810

 

  • Khan A.S., Murray M.J., Ho C.M.K., Zuercher W.J., Reeves M.B. & Strang B.L. (2017) High throughput screening of GlaxoSmithKline Protein Kinase Inhibitor Set Identifies an Inhibitor of Human Cytomegalovirus Replication that Prevents CREB and Histone H3 Post Translational Modification. J. Gen. Virol. 754-68

 

  • Lassalle F., Depledge D., Reeves M.B. et al (2016) in an ocean pervasive recombination reveals two-speed evolution human cytomegalovirus genomes. vew017

 

REVIEWS/ EDITORIALS/ PERSPECTIVES

 

  • Gomes, A.C.; Griffiths, P.D.; Reeves, M.B. The Humoral Immune Response Against the gB Vaccine: Lessons Learnt from Protection in Solid Organ Transplantation. Vaccines 2019, 7, 67.
     

  • Chong, S, Antoni, M, Macdonald, A, Reeves, M, Harber, M, Magee, CN. BK virus: Current understanding of pathogenicity and clinical disease in transplantation. Rev Med Virol. 2019; 29:e2044. https://doi.org/10.1002/rmv.2044
     

  • Murray M.J., Peters, N.E. & Reeves M.B. (2018) Navigating the host cell response during entry into sites of latent cytomegalovirus infection. Pathogens 7(1). pii: E30.

 

  • Reeves M.B. (2018) Viral programming of progenitor cell commitment Nat. Micro.4: 398-99

 

  • Baraniak I., Reeves M.B. & Griffiths P. (2018) Criteria to define interruption of transmission of human cytomegalovirus from organ donor to recipient Rev. Med. Virol. 28(1): doi: 10.1002/rmv.1958

 

  • Reeves M.B. (2017) Viral Regulation of Cell Death (2017) Invited Editorial J. Mol. Biochem 6(1): 1-2

 

  • Griffiths P.D. & Reeves M.B. (2017) Chapter 23: Cytomegalovirus pp481-510

 

  • Dupont L. & Reeves M.B. (2016) Cytomegalovirus latency and reactivation: Recent insights into an age old problem. Reviews in Medical Virology. 26(2): 75-89

 

  • Griffiths P., Baraniak I. & Reeves M.B. (2015) The pathogenesis of human cytomegalovirus. Journal of Pathology 235(2): 288-97​

Key Publications
  • Poole E.L., Lau J.C.H., Murray, M.J., Kew V.G., Stamminger T., Sinclair J.H. & Reeves M.B. (2018) A virally dependent de-sumoylase activity is required for HCMV reactivation from latency Cell Reports 24(3):594-606

  • Baraniak I, Kropff B, Ambrose L, McIntosh M, McLean, G, Pichon S,Atkinson C, Milne R.,Mach, M., Griffiths P. & Reeves M.B. (2018) Protection from cytomegalovirus viraemia following glycoprotein B vaccination is not dependent on neutralising antibodies PNAS 115(24):6273-627see

  • Baraniak I.... Reeves M.B. (2018) Epitope mapping of the humoral immune response against HCMV glycoprotein B following vaccination with gB/MF59 prior to transplant. Journal of Infectious Diseases jiy102, https://doi.org/10.1093/infdis/jiy102

  • Kew V.G., Yuan, J., Meier, J. & Reeves M.B. (2014) Mitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus gene expression from latency. PLoS Pathogens10(6):e1004195

 

  • Huang M.M., Kew V.G., Jestice K., Wills M.R. & Reeves M.B. (2012) Efficient human cytomegalovirus reactivation is maturation dependent in the Langerhans dendritic cell lineage and can be studied using a CD14+ experimental latency model. J. Virol. 86(16):8507-15

 

  • Reeves M.B., Breidenstein A. & Compton T. (2012) Human cytomegalovirus activation of ERK and myeloid cell leukaemia-1 protein correlates with survival of latently infected cells. PNAS 109(2): 588-93

 

  • Reeves M.B. & Compton T. (2011) Inhibition of inflammatory interleukin-6 activity via extracellular signal-related-mitogen activated protein kinase antagonizes human cytomegalovirus reactivation from dendritic cells. J. Virol. 85(23): 12750-8

 

  • Reeves M.B., Davies A.A., McSharry B.P., Wilkinson G.W. and Sinclair J.H. (2007) A virally encoded RNA molecule protects infected cells from mitochondrial-induced cell death. Science 316(5829): 1345-8 see also Perspectives section in Science 317(5836):  329-30

  • Reeves M.B., Lehner P.J., Sissons J.G.P. and Sinclair J.H. (2005) An in vitro model for the regulation of HCMV latency and reactivation in dendritic cells by chromatin remodeling. J. Gen. Virol 86(11): 2949-54

 

  • Reeves M.B., MacAry P.A., Lehner P.J., Sissons J.G.P. and Sinclair J.H. (2005) Latency, chromatin remodeling and reactivation of HCMV in the dendritic cells of healthy carriers. PNAS 102(11): 4140-5

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